The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning
Identifieur interne : 002C93 ( Main/Exploration ); précédent : 002C92; suivant : 002C94The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning
Auteurs : L. Clark [Royaume-Uni] ; R. Cools [Royaume-Uni] ; T. W. Robbins [Royaume-Uni]Source :
- Brain and cognition : (Print) [ 0278-2626 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Converging evidence from human lesion, animal lesion, and human functional neuroimaging studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-making and reversal learning. The ascending 5-HT and dopamine neurotransmitter systems have a modulatory role in both processes. There is accumulating evidence that measures of decision-making and reversal learning may be useful as functional markers of ventral prefrontal cortex integrity in psychiatric and neurological disorders. Whilst existing measures of decision-making may have superior sensitivity, reversal learning may offer superior selectivity, particularly within prefrontal cortex. Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning.
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Clark</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Experimental Psychology, University of Cambridge</s1><s2>Cambridge CB2 3EB</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Cools, R" sort="Cools, R" uniqKey="Cools R" first="R." last="Cools">R. Cools</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Experimental Psychology, University of Cambridge</s1><s2>Cambridge CB2 3EB</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Robbins, T W" sort="Robbins, T W" uniqKey="Robbins T" first="T. W." last="Robbins">T. W. Robbins</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Experimental Psychology, University of Cambridge</s1><s2>Cambridge CB2 3EB</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></analytic><series><title level="j" type="main">Brain and cognition : (Print)</title><title level="j" type="abbreviated">Brain cogn. : (Print)</title><idno type="ISSN">0278-2626</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain and cognition : (Print)</title><title level="j" type="abbreviated">Brain cogn. : (Print)</title><idno type="ISSN">0278-2626</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acquisition process</term><term>Addiction</term><term>Animal</term><term>Cognition</term><term>Decision making</term><term>Dopamine</term><term>Human</term><term>Orbitofrontal cortex</term><term>Parkinson disease</term><term>Prefrontal cortex</term><term>Psychopathia</term><term>Reversal learning</term><term>Review</term><term>Risk taking</term><term>Serotonin</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex préfrontal</term><term>Cortex orbitofrontal</term><term>Sérotonine</term><term>Dopamine</term><term>Prise risque</term><term>Addiction</term><term>Psychopathie</term><term>Prise décision</term><term>Apprentissage inversion</term><term>Article synthèse</term><term>Parkinson maladie</term><term>Processus acquisition</term><term>Cognition</term><term>Homme</term><term>Animal</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Converging evidence from human lesion, animal lesion, and human functional neuroimaging studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-making and reversal learning. The ascending 5-HT and dopamine neurotransmitter systems have a modulatory role in both processes. There is accumulating evidence that measures of decision-making and reversal learning may be useful as functional markers of ventral prefrontal cortex integrity in psychiatric and neurological disorders. Whilst existing measures of decision-making may have superior sensitivity, reversal learning may offer superior selectivity, particularly within prefrontal cortex. Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Clark, L" sort="Clark, L" uniqKey="Clark L" first="L." last="Clark">L. Clark</name></region><name sortKey="Cools, R" sort="Cools, R" uniqKey="Cools R" first="R." last="Cools">R. Cools</name><name sortKey="Robbins, T W" sort="Robbins, T W" uniqKey="Robbins T" first="T. W." last="Robbins">T. W. Robbins</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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